Mortality involving New Psychoactive Substances across Europe, 2016-2017

New psychoactive substances (NPS) are new narcotic or psychotropic drugs that are not controlled by the drug conventions of the United Nations. In the last 10 years, numerous NPS have been identified in Europe but there is no comprehensive overview of mortality related to them. This study aims to estimate the mortality related to NPS in Europe in 2016 and 2017. The number of drug-related deaths (DRD) 2016-2017 was retrieved from a) the annual national reports of European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) countries (Statistical Bulletin (2018/2019) and ‘Harms and harm reduction workbooks’ (2017/2018)) and b) EMCDDA Risk Assessment Reports of the EU Early Warning System on several specific NPS (2017-2018). Population data was retrieved from Eurostat (2016/2017). Incidence of DRD and of DRD involving at least one NPS was calculated. Of all DRD recorded in Europe, 11.7% in 2016 and 18.1% in 2017 involved at least one NPS (NPS-DRD), from 2.7 to 4.9 deaths per million of 15 to 64-year-old inhabitants. Between 2016 and 2017, a significant increase was observed (30%, odds ratio 1.33, CI95% 1.26-1.45, p