Modeling of p-aminophenol compounds as analgesic antiinflammatory based on biologic activity and structure relationship

This research aim was to find out the new compounds model of paminophenol derivates which have analgesic anti-inflammatory activity based on structure and biologic activity relationship analysis by computation methods. Seventeen compounds of p-aminophenol derivates were used in this research, and six compounds known its analgesic-antiinflammatory activity were used for determine QSAR equation model. This research’s result was a QSAR equation that can be using for synthesis the higher activity new compound of paminophenol. Key words : p-aminophenol compounds, analgesic anti-inflammatory activity, structure and activity relationship, QSAR equation, computation methods