Relationship between chromosomal aberrations and gene expressions in the p53 pathway in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is a neoplasm characterized by excessive accumulation of B lymphocytes in the peripheral blood, bone marrow and lymph nodes. We assessed the expressions of 22 genes in the p53 pathway in 30 CLL patients and 15 healthy subjects by a RT2 Profiler PCR (polymerase chain reaction) Array technique and their relation to cytogenetic aberrations detected by fluorescent hybridization (FISH). Our Student’s -test results indicated that and BCL2 genes were statistically significant (