Identification of commonly altered genes between in major depressive disorder and a mouse model of depression

Identification of commonly altered genes between in major depressive disorder and a mouse model of depression

The heterogeneity of depression (due to factors such as varying age of onset) may explain why biological markers of major depressive disorder (MDD) remain uncertain. We aimed to identify gene expression markers of MDD in leukocytes using microarray analysis. We analyzed gene expression profiles of p...

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Veröffentlicht in:Scientific reports 2017-06, Vol.7 (1), p.3044-10, Article 3044
Hauptverfasser: Yamagata, Hirotaka, Uchida, Shusaku, Matsuo, Koji, Harada, Kenichiro, Kobayashi, Ayumi, Nakashima, Mami, Nakano, Masayuki, Otsuki, Koji, Abe-Higuchi, Naoko, Higuchi, Fumihiro, Watanuki, Toshio, Matsubara, Toshio, Miyata, Shigeo, Fukuda, Masato, Mikuni, Masahiko, Watanabe, Yoshifumi
Format: Artikel
Sprache:eng
Schlagworte:
38/61
692/53/2421
692/699/476/1414
Age
Aged
Animals
Biomarkers
Depression - genetics
DNA microarrays
Female
Gene expression
Gene Expression Profiling
Heterogeneity
Histones - genetics
Histones - metabolism
Humanities and Social Sciences
Humans
Leukocytes
Male
Mental depression
Mice
Mice, Inbred BALB C
Middle Aged
multidisciplinary
Polymerase chain reaction
Science
Science (multidisciplinary)
Transcriptome
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Zusammenfassung:The heterogeneity of depression (due to factors such as varying age of onset) may explain why biological markers of major depressive disorder (MDD) remain uncertain. We aimed to identify gene expression markers of MDD in leukocytes using microarray analysis. We analyzed gene expression profiles of patients with MDD (age ≥50, age of depression onset
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-03291-x