Depletion of regulatory T-cells leads to moderate B-cell antigenicity in respiratory syncytial virus infection

Depletion of regulatory T-cells leads to moderate B-cell antigenicity in respiratory syncytial virus infection

Highlights • Regulatory T-cells (Tregs) participate in modulating respiratory syncytial virus (RSV)-induced exacerbated disease. • Treg depletion decreases anti-fusion and neutralizing antibodies in RSV-infected mice. • The way in which B cell antigenicity is modulated by Tregs is CD4+ T-cell-depend...

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Veröffentlicht in:International journal of infectious diseases 2015-12, Vol.41 (C), p.56-64
Hauptverfasser: Shao, Hsiao-Yun, Huang, Juo-Yu, Lin, Yi-Wen, Yu, Shu-Ling, Chitra, Ebenezer, Chang, Ching-Kun, Sung, Wang-Chou, Chong, Pele, Chow, Yen-Hung
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antibodies, Neutralizing
Antibodies, Viral
Antigenicity
B-cells
B-Lymphocytes - physiology
CD8-Positive T-Lymphocytes - immunology
Female
Infectious Disease
Lung - pathology
Mice
Mice, Inbred BALB C
Mice, SCID
Pulmonary/Respiratory
Regulatory T-cells
Respiratory syncytial virus
Respiratory Syncytial Virus Infections - immunology
Respiratory Syncytial Virus Infections - virology
Respiratory Syncytial Viruses - immunology
Spleen - pathology
T-Lymphocytes, Regulatory - physiology
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Beschreibung
Zusammenfassung:Highlights • Regulatory T-cells (Tregs) participate in modulating respiratory syncytial virus (RSV)-induced exacerbated disease. • Treg depletion decreases anti-fusion and neutralizing antibodies in RSV-infected mice. • The way in which B cell antigenicity is modulated by Tregs is CD4+ T-cell-dependent. • Passive transfer of Treg-depleted B cells into SCID mice enhances RSV pathogenesis.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2015.10.026