High Dietary Fructose Intake on Cardiovascular Disease Related Parameters in Growing Rats

The objective of this study was to determine the effects of a high-fructose diet on cardiovascular disease (CVD)-related parameters in growing rats. Three-week-old female Sprague Dawley rats were randomly assigned to four experimental groups; a regular diet group (RD: fed regular diet based on AIN-9...

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Veröffentlicht in:Nutrients 2016-12, Vol.9 (1), p.11
Hauptverfasser: Yoo, SooYeon, Ahn, Hyejin, Park, Yoo Kyoung
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Sprache:eng
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Zusammenfassung:The objective of this study was to determine the effects of a high-fructose diet on cardiovascular disease (CVD)-related parameters in growing rats. Three-week-old female Sprague Dawley rats were randomly assigned to four experimental groups; a regular diet group (RD: fed regular diet based on AIN-93G, = 8), a high-fructose diet group (30Frc: fed regular diet with 30% fructose, = 8), a high-fat diet group (45Fat: fed regular diet with 45 kcal% fat, = 8) or a high fructose with high-fat diet group (30Frc + 45Fat, fed diet 30% fructose with 45 kcal% fat, = 8). After an eight-week treatment period, the body weight, total-fat weight, serum glucose, insulin, lipid profiles and pro-inflammatory cytokines, abdominal aortic wall thickness, and expressions of eNOS and ET-1 mRNA were analyzed. The result showed that total-fat weight was higher in the 30Frc, 45Fat, and 30Frc + 45Fat groups compared to the RD group ( < 0.05). Serum triglyceride (TG) levels were highest in the 30Frc group than the other groups ( < 0.05). The abdominal aorta of 30Frc, 45Fat, and 30Frc + 45Fat groups had higher wall thickness than the RD group ( < 0.05). Abdominal aortic eNOS mRNA level was decreased in 30Frc, 45Fat, and 30Frc + 45Fat groups compared to the RD group ( < 0.05), and also 45Fat and 30Frc + 45Fat groups had decreased mRNA expression of eNOS compared to the 30Frc group ( < 0.05). ET-1 mRNA level was higher in 30Frc, 45Fat, and 30Frc + 45Fat groups than the RD group ( < 0.05). Both high fructose consumption and high fat consumption in growing rats had similar negative effects on CVD-related parameters.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu9010011