Evaluation of the C60 biodistribution in mice in a micellar ExtraOx form and in an oil solution

Evaluation of the C60 biodistribution in mice in a micellar ExtraOx form and in an oil solution

The article is devoted to the study of the pharmacokinetics of fullerene C 60 in oil and micellar forms, analysis of its content in blood, liver, lungs, kidneys, heart, brain, adrenal glands, thymus, testicles, and spleen. The highest accumulation of C 60 was found in the liver and adrenal glands. A...

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Veröffentlicht in:Scientific reports 2021-04, Vol.11 (1), p.1-13, Article 8362
Hauptverfasser: Semenov, Konstantin N., Ivanova, Daria A., Ageev, Sergei V., Petrov, Andrey V., Podolsky, Nikita E., Volochaeva, Ekaterina M., Fedorova, Ekaterina M., Meshcheriakov, Anatolii A., Zakharov, Egor E., Murin, Igor V., Sharoyko, Vladimir V.
Format: Artikel
Sprache:eng
Schlagworte:
631/61/54/990
639/301/357/73
639/925/350/2093
Adrenal glands
Bioavailability
Fullerenes
Humanities and Social Sciences
Kidneys
Liver
multidisciplinary
Oil
Pharmacokinetics
Science
Science (multidisciplinary)
Spleen
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Zusammenfassung:The article is devoted to the study of the pharmacokinetics of fullerene C 60 in oil and micellar forms, analysis of its content in blood, liver, lungs, kidneys, heart, brain, adrenal glands, thymus, testicles, and spleen. The highest accumulation of C 60 was found in the liver and adrenal glands. As a result of the studies carried out, it was shown that the bioavailability of C 60 in the micellar form is higher than that in an oil solution.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-87014-3