Osilodrostat‐induced adrenal insufficiency in a patient with Cushing's disease

Cushing's disease is a rare condition caused by a benign pituitary tumor underlying adrenocorticotropic hormone excess. Medical treatment is implemented when surgical resection is not curative. We present a case of Cushing's disease with recurrence of macroadenoma who developed iatrogenic adrenal insufficiency in the setting of Osilodrostat treatment. Monitoring side effects and biochemical efficacy of treatment in patients with Cushing's disease is of utmost importance, particularly when initiating therapy and when adjusting dosages to avoid complications including adrenal insufficiency.