New Anticandidous 2-Alkylthio-6-aminobenzothiazoles

New Anticandidous 2-Alkylthio-6-aminobenzothiazoles

The synthesis and antimicrobial activity of six new 2-alkenyl-6-aminobenzothiazoles are reported. The new compounds were prepared by alkenylation of the potassium salt of 6-amino-2-mercaptobenzothiazole with alkenyl bromides. The structure of the compounds was verified by 1H NMR spectra. The compoun...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 1997-02, Vol.2 (2), p.36-42
Hauptverfasser: Sidóová, Eva, Loos, Dusan, Bujdáková, Helena, Kallová, Jana
Format: Artikel
Sprache:eng
Schlagworte:
2-Alkenylthio-6-aminobenzothiazoles
AM1 calculations
antibacterial
anticandidous
Antimicrobial agents
Biological activity
lipophilicity
Sterols
Sulfur
Yeast
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Beschreibung
Zusammenfassung:The synthesis and antimicrobial activity of six new 2-alkenyl-6-aminobenzothiazoles are reported. The new compounds were prepared by alkenylation of the potassium salt of 6-amino-2-mercaptobenzothiazole with alkenyl bromides. The structure of the compounds was verified by 1H NMR spectra. The compounds have shown antibacterial activity against Staphylococcus aureus and anticandidous activity against Candida albicans. The optimum structure of the studied compounds has been calculated by quantum chemistry AM1 method. The theoretical values of lipophilicity were calculated for all alkenyl substituents.
ISSN:1420-3049
1420-3049
DOI:10.3390/feb97p2