Risperidone-Induced sexual dysfunction reverted with aripiprazole: Experience from two cases

Antipsychotic agents are effective in schizophrenia by alleviating positive and negative symptoms, but also have the potential for inducing sexual dysfunction by causing hyperprolactinemia. This may have a negative impact on treatment compliance. Risperidone is associated with a high rate of sexual dysfunction compared to olanzapine, clozapine, quetiapine, and aripiprazole. However, the partial dopaminergic agonism of aripiprazole at D2receptor may explain why its use does not usually cause this side effect and may even revert it when added to another antipsychotic. We present here two cases of schizophrenia, who were treated with risperidone, and complained of sexual dysfunction during follow-up. After the addition of aripiprazole and reducing the dose of risperidone, this side effect reverted without a negative impact on treatment adherence or therapeutic efficacy.