Effect of the particle shape on the particle dynamics in a spheronization process

Spherical granules with a narrow size distribution are widely used in many pharmaceutical applications. Extrusion-spheronization is a well-established process to produce such pharmaceutical pellets. The cylindrical extrudates from the extrusion step are rounded in the spheronizer. The formation mech...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:EPJ Web of conferences 2017-01, Vol.140, p.15005
Hauptverfasser: Weis, Dominik, Niesing, Maria, Thommes, Markus, Antonyuk, Sergiy
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Spherical granules with a narrow size distribution are widely used in many pharmaceutical applications. Extrusion-spheronization is a well-established process to produce such pharmaceutical pellets. The cylindrical extrudates from the extrusion step are rounded in the spheronizer. The formation mechanisms inside of a spheronizer depend strongly on the particle dynamics. To describe the complex particle flow and interactions, the Discrete Element Method can be used. In our previous works the spherical particles during the last part of the spheronization process were studied. Since the pellets have a cylindrical shape at the beginning and undergo different stages of deformation during the rounding process, the objective of this study was the description of the influence of the particle shape on the particle dynamics. To predict the interactions of the pellets, their dominant plastic behaviour was described with an appropriate contact model and the material parameters were calibrated with compression and impact tests.
ISSN:2100-014X
2101-6275
2100-014X
DOI:10.1051/epjconf/201714015005