A heterozygous MYBPC3 (c. 772+1G > A) mutant human induced pluripotent stem cell line (ZZUNEUi025-A) generated from a male patient with hypertrophic cardiomyopathy

A heterozygous MYBPC3 (c. 772+1G > A) mutant human induced pluripotent stem cell line (ZZUNEUi025-A) generated from a male patient with hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is the most common heterogeneous myocardial disease. MYBPC3 variants are the leading cause of HCM. In the present study, a human induced pluripotent stem cell (iPSC) line ZZUNEUi025-A was generated from peripheral blood mononuclear cells of a male HCM patient with c...

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Veröffentlicht in:Stem cell research 2022-04, Vol.60, p.102722-102722, Article 102722
Hauptverfasser: Zhao, Xi, Cao, Jinhua, Li, Xiaowei, Liu, Mengduan, Liu, Yangyang, Dong, Jianzeng, Zhao, Xiaoyan
Format: Artikel
Sprache:eng
Schlagworte:
Cardiomyopathy, Hypertrophic - genetics
Cytoskeletal Proteins - genetics
Heterozygote
Humans
Induced Pluripotent Stem Cells
Leukocytes, Mononuclear
Male
Mutation - genetics
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Zusammenfassung:Hypertrophic cardiomyopathy (HCM) is the most common heterogeneous myocardial disease. MYBPC3 variants are the leading cause of HCM. In the present study, a human induced pluripotent stem cell (iPSC) line ZZUNEUi025-A was generated from peripheral blood mononuclear cells of a male HCM patient with c. 772+1G > A in MYBPC3 gene. This cell line expressed pluripotency markers, had normal male karyotype and could differentiate into three germ layers in vitro.
ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2022.102722