Total synthesis of antiviral drug, nirmatrelvir (PF-07321332)

Total synthesis of antiviral drug, nirmatrelvir (PF-07321332)

The emergence and rapid spread of coronavirus disease 2019 (COVID-19), a potentially fatal disease, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has swiftly led to public health crisis worldwide. Hence vaccines and antiviral therapeutics are an important part of the health...

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Veröffentlicht in:Tetrahedron chem 2022-12, Vol.4, p.100033-100033, Article 100033
Hauptverfasser: Shekhar, Chandra, Nasam, Rajesh, Paipuri, Siva Ramakrishna, Kumar, Prakash, Nayani, Kiranmai, Pabbaraja, Srihari, Mainkar, Prathama S., Chandrasekhar, Srivari
Format: Artikel
Sprache:eng
Schlagworte:
Amino acid
Antiviral drug
COVID-19
Cyclopropanation
Peptide
Peptide coupling
Protein mimetic
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Zusammenfassung:The emergence and rapid spread of coronavirus disease 2019 (COVID-19), a potentially fatal disease, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has swiftly led to public health crisis worldwide. Hence vaccines and antiviral therapeutics are an important part of the healthcare response to combat the ongoing threat by COVID-19. Here, we report an efficient synthesis of nirmatrelvir (PF-07321332), an orally active SARS-CoV-2 main protease inhibitor. [Display omitted]
ISSN:2666-951X
2666-951X
DOI:10.1016/j.tchem.2022.100033