Cardioprotective effects of sinomenine in myocardial ischemia/reperfusion injury in a rat model

Ischemia reperfusion (I/R) play an imperative role in the expansion of cardiovascular disease. Sinomenine (SM) has been exhibited to possess antioxidant, anticancer, anti-inflammatory, antiviral and anticarcinogenic properties. The aim of the study was scrutinized the cardioprotective effect of SM a...

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Veröffentlicht in:Saudi pharmaceutical journal 2022-06, Vol.30 (6), p.669-678
Hauptverfasser: Lu, Changhong, Guo, Xiao, He, Xianghui, Chang, Yu, Zheng, Fa, Xu, Chenji, Zhang, Shuwen, Zhou, Yaqun, Li, Junfang
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Sprache:eng
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Zusammenfassung:Ischemia reperfusion (I/R) play an imperative role in the expansion of cardiovascular disease. Sinomenine (SM) has been exhibited to possess antioxidant, anticancer, anti-inflammatory, antiviral and anticarcinogenic properties. The aim of the study was scrutinized the cardioprotective effect of SM against I/R injury in rat. Rat were randomly divided into normal control (NC), I/R control and I/R + SM (5, 10 and 20 mg/kg), respectively. Ventricular arrhythmias, body weight and heart weight were estimated. Antioxidant, inflammatory cytokines, inflammatory mediators and plasmin system indicator were accessed. Pre-treated SM group rats exhibited the reduction in the duration and incidence of ventricular fibrillation, ventricular ectopic beat (VEB) and ventricular tachycardia along with suppression of arrhythmia score during the ischemia (30 and 120 min). SM treated rats significantly (P 
ISSN:1319-0164
2213-7475
DOI:10.1016/j.jsps.2022.04.005