Synthesis of Some More Fluorine Heterocyclic Nitrogen Systems Derived From Sulfa Drugs as Photochemical Probe Agents for Inhibition of Vitiligo Disease‐Part I

Some more new bioactive fluorine heterocyclic systems containing sulfur and nitrogen as five‐membered rings: pyrazoline, imidazole, imidazolopyrimidine, thiazolidinone and 1,2,4‐triazole derivatives (3‐13) have been synthetically derived from the interaction of sulfa drugs with fluorine aromatic aldehyde and/or hexa fluoroacetic anhydride followed by heterocyclization reactions. Former structures of the targets have been deduced upon the help of elemental and spectral data.. Compounds 7a‐f, 10c and 13 could be used as photochemical probe agents for inhibition of Vitiligo diseases, in compare with Nystatin and Nalidixic acid.