GAS5 rs2067079 and miR-137 rs1625579 functional SNPs and risk of chronic hepatitis B virus infection among Egyptian patients

GAS5 rs2067079 and miR-137 rs1625579 functional SNPs and risk of chronic hepatitis B virus infection among Egyptian patients

Hepatitis B virus (HBV) infection is a significant health issue worldwide.. We attempted to fulfill the molecular mechanisms of epigenetic and genetic factors associated with chronic HBV (CHBV). Expression levels of the lncRNA growth arrest-specific 5 (GAS5) and miR-137 and their corresponding SNPs,...

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Veröffentlicht in:Scientific reports 2021-10, Vol.11 (1), p.20014-20014, Article 20014
Hauptverfasser: Mahmoud, Rania H., Hefzy, Enas Mamdouh, Shaker, Olfat G., Ahmed, Tarek I., Abdelghaffar, Noha K., Hassan, Essam A., Ibrahim, Amal A., Ali, Doaa Y., Mohamed, Mohamed M., Abdelaleem, Omayma O.
Format: Artikel
Sprache:eng
Schlagworte:
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Adult
Biomarkers - analysis
Chronic infection
Egypt - epidemiology
Epigenetics
Female
Genetic factors
Genetic Predisposition to Disease
Genotype & phenotype
Genotypes
Hepatitis
Hepatitis B
Hepatitis B - epidemiology
Hepatitis B - genetics
Hepatitis B, Chronic - epidemiology
Hepatitis B, Chronic - genetics
Humanities and Social Sciences
Humans
Male
MicroRNAs - analysis
MicroRNAs - genetics
Molecular modelling
multidisciplinary
Mutants
Polymorphism, Single Nucleotide
Risk factors
RNA, Long Noncoding - analysis
RNA, Long Noncoding - genetics
Science
Science (multidisciplinary)
Single-nucleotide polymorphism
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Zusammenfassung:Hepatitis B virus (HBV) infection is a significant health issue worldwide.. We attempted to fulfill the molecular mechanisms of epigenetic and genetic factors associated with chronic HBV (CHBV). Expression levels of the lncRNA growth arrest-specific 5 (GAS5) and miR-137 and their corresponding SNPs, rs2067079 (C/T) and rs1625579 (G/T) were analyzed in 117 CHBV patients and 120 controls to investigate the probable association between these biomarkers and CHBV pathogenesis in the Egyptian population. Serum expression levels of GAS5 and miR-137 were significantly down-regulated in cases vs controls. Regarding GAS5 (rs2067079), the mutant TT genotype showed an increased risk of CHBV ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-99345-2