Pancytopenia in a Case of Aplastic Anaemia/Paroxysmal Nocturnal Haemoglobinuria Unmasked by SARS-CoV-2 Infection: A Case Report

During an acute SARS-CoV-2 infection, a diagnosis of Aplastic Anaemia associated with Paroxysmal Nocturnal Haemoglobinuria (AA/PNH) was made in a 78-year-old woman who had presented to the emergency department with severe pancytopenia. It is possible that she had subclinical AA/PNH that was unmasked...

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Veröffentlicht in:	Medicina (Kaunas, Lithuania) Lithuania), 2022-09, Vol.58 (9), p.1282
Hauptverfasser:	Iannuzzi, Arcangelo, Parrella, Antonio, De Ritis, Francesca, Cammarota, Anna, Berloco, Lucia, Paudice, Francesca, D’Angelo, Giovanni, Aliberti, Emilio, Iannuzzo, Gabriella
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Age Anemia Antibodies Antigens aplastic anaemia Aplastic anemia Bone marrow Case Report Case reports Case studies Cloning Coronaviruses COVID-19 Diagnosis Granulocytes Hemoglobinuria, Paroxysmal Infections Pancytopenia Pandemics Paroxysmal Nocturnal Haemoglobinuria Pathogenesis Patients PIGA gene Proteins Severe acute respiratory syndrome coronavirus 2 Thrombosis
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Zusammenfassung:	During an acute SARS-CoV-2 infection, a diagnosis of Aplastic Anaemia associated with Paroxysmal Nocturnal Haemoglobinuria (AA/PNH) was made in a 78-year-old woman who had presented to the emergency department with severe pancytopenia. It is possible that she had subclinical AA/PNH that was unmasked during the acute COVID-19 infection, but we can also suspect a direct role of the virus in the pathogenesis of the disease, or we can hypothesize that COVID-19 infection changed the phosphatidylinositol glycan class A (PIGA) gene pathway.
ISSN:	1648-9144 1010-660X 1648-9144
DOI:	10.3390/medicina58091282