Lasia spinosa (L.) thw. attenuates chemically induced behavioral disorders in experimental and computational models

Lasia spinosa (L.) Thw. (L. spinosa) is widely used as a folk remedy for different physical ailments, and its neurological effects have yet to be assessed. Phytochemicals status of L. spinosa was evaluated by GC-MS analysis. Membrane stabilization test, elevated plus maze (EPM) tests and hole board...

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Veröffentlicht in:	Heliyon 2023-06, Vol.9 (6), p.e16754-e16754, Article e16754
Hauptverfasser:	Reza, A.S.M. Ali, Sakib, Mahfuz Ahmed, Nasrin, Mst. Samima, Khan, Jishan, Khan, Mohammad Forhad, Hossen, Md. Amjad, Ali, Md. Hazrat, Haque, Md. Anwarul
Format:	Artikel
Sprache:	eng
Schlagworte:	And PASS Antidepressant Anxiolytic activity Hemolysis inhibition Lasia spinosa Molecular docking
Online-Zugang:	Volltext
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Zusammenfassung:	Lasia spinosa (L.) Thw. (L. spinosa) is widely used as a folk remedy for different physical ailments, and its neurological effects have yet to be assessed. Phytochemicals status of L. spinosa was evaluated by GC-MS analysis. Membrane stabilization test, elevated plus maze (EPM) tests and hole board tests (HBT), tail suspension tests (TST) and thiopental sodium-induced sleeping tests (TISTT) were used to assess anti-inflammatory, anxiolytic and anti-depressant activity. Fourteen compounds have been recorded from GC-MS analysis. The LSCTF showed 68.66 ± 2.46% hemolysis protections (p
ISSN:	2405-8440 2405-8440
DOI:	10.1016/j.heliyon.2023.e16754