Immunoglobulin genes and diversity: what we have learned from domestic animals

This review focuses on the diversity of immunoglobulin (Ig) genes and Ig isotypes that are expressed in domestic animals. Four livestock species--cattle, sheep, pigs, and horses--express a full range of Ig heavy chains (IgHs), including t J, 6, y, c, and a. Two poultry species (chickens and ducks) e...

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Veröffentlicht in:Journal of Animal Science and Biotechnology 2012-06, Vol.3 (4), p.176-180, Article 18
Hauptverfasser: Sun, Yi, Liu, Zhancai, Ren, Liming, Wei, Zhiguo, Wang, Ping, Li, Ning, Zhao, Yaofeng
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Sprache:eng
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Zusammenfassung:This review focuses on the diversity of immunoglobulin (Ig) genes and Ig isotypes that are expressed in domestic animals. Four livestock species--cattle, sheep, pigs, and horses--express a full range of Ig heavy chains (IgHs), including t J, 6, y, c, and a. Two poultry species (chickens and ducks) express three IgH isotypes, la, u, and a, but not (5. The K and X light chains are both utilized in the four livestock species, but only the X chain is expressed in poultry. V(D)J recombination, somatic hypermutation (SHM), and gene conversion (GC) are three distinct mechanisms by which immunoglobulin variable region diversity is generated. Different domestic animals may use distinct means to diversifyrearrancled variable reqions of la aenes.
ISSN:1674-9782
2049-1891
2049-1891
DOI:10.1186/2049-1891-3-18