New-onset Chronic Kidney Disease After Surgery for Localised Renal Masses in Patients with Two Kidneys and Preserved Renal Function: A Contemporary Multicentre Study

The risk of acute kidney injury and clinically significant chronic kidney disease in patients with two kidneys and preserved baseline renal function undergoing surgery for a localised renal mass is not clinically negligible, especially in those with higher-complexity tumours. Partial nephrectomy should be prioritised over radical nephrectomy if oncological outcomes are not jeopardised. There is a lack of evidence on acute kidney injury (AKI) and new-onset chronic kidney disease (CKD) after surgery for localised renal masses (LRMs) in patients with two kidneys and preserved baseline renal function. To evaluate the prevalence and risk of AKI and new-onset clinically significant CKD (csCKD) in patients with a single renal mass and preserved renal function after being treated with partial (PN) or radical (RN) nephrectomy. We queried our prospectively maintained databases to identify patients with a preoperative estimated glomerular filtration rate (eGFR) of ≥60 ml/min/1.73 m2 and a normal contralateral kidney who underwent PN or RN for a single LRM (cT1-T2N0M0) between January 2015 and December 2021 at four high-volume academic institutions. PN or RN. The outcomes of this study were AKI at hospital discharge and the risk of new-onset csCKD, defined as eGFR