Association between serum total indoxyl sulfate, intraperitoneal inflammation, and peritoneal dialysis technique failure: a 3-year prospective cohort study

Association between serum total indoxyl sulfate, intraperitoneal inflammation, and peritoneal dialysis technique failure: a 3-year prospective cohort study

The impact of protein-bound uremic toxins, specifically indoxyl sulfate (IS) on peritoneal dialysis (PD) complications remains controversial. This study aimed to explore the link between serum total IS (tIS) levels, proinflammatory cytokines in serum and peritoneal dialysis effluent (PDE), and PD te...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:BMC nephrology 2024-12, Vol.25 (1), p.475-13, Article 475
Hauptverfasser: Stepanova, Natalia, Driianska, Victoria, Korol, Lesya, Snisar, Lyudmyla
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Blood pressure
Cholesterol
Clinical outcomes
Cohort analysis
Cohort Studies
Complications and side effects
Continuous ambulatory peritoneal dialysis
Creatinine
Cytokines
Cytokines - blood
Diabetes mellitus
Diagnosis
Dialysate
Dialysis technique failure
Female
Glucose
Health aspects
Hemodialysis
Hemoglobin
High density lipoprotein
Humans
Indican - blood
Inflammation
Inflammation - blood
Interleukin 6
Kidney diseases
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - therapy
Male
Measurement
Middle Aged
Monocyte chemoattractant protein 1
Nephrology
Patients
Peritoneal Dialysis
Peritoneum
Peritonitis
Peritonitis - blood
Peritonitis - epidemiology
Peritonitis - etiology
Plasma
Prospective Studies
Proteins
Risk assessment
Risk factors
Sample size
Sulfates
Survival analysis
Total indoxyl sulfate
Toxins
Treatment Failure
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Urine
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The impact of protein-bound uremic toxins, specifically indoxyl sulfate (IS) on peritoneal dialysis (PD) complications remains controversial. This study aimed to explore the link between serum total IS (tIS) levels, proinflammatory cytokines in serum and peritoneal dialysis effluent (PDE), and PD technique survival. In this prospective cohort study, 84 patients were followed up for three years and analyzed. Stratification into low-tIS (
ISSN:1471-2369
1471-2369
DOI:10.1186/s12882-024-03935-x