LncRNA EIF3J-AS1 enhanced esophageal cancer invasion via regulating AKT1 expression through sponging miR-373-3p

LncRNA EIF3J-AS1 enhanced esophageal cancer invasion via regulating AKT1 expression through sponging miR-373-3p

Esophageal cancer (ECa) remains a major cause of mortality across the globe. The expression of EIF3J-AS1 is altered in a plethora of tumors, but its role in ECa development and progression are undefined. Here, we show that EIF3J-AS1 is up-regulated in ECa and that its expression correlates with adva...

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Veröffentlicht in:Scientific reports 2020-08, Vol.10 (1), p.13969-9, Article 13969
Hauptverfasser: Wei, Wei-tian, Wang, Liang, Liang, Jin-xiao, Wang, Jiang-feng, Li, Qing, Zeng, Jian
Format: Artikel
Sprache:eng
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Adult
Aged
Aged, 80 and over
AKT1 protein
Apoptosis - physiology
Carcinogenesis
Cell Line, Tumor
Cell Movement - physiology
Cell Proliferation - physiology
Disease Progression
Esophageal cancer
Esophageal Neoplasms - genetics
Esophageal Neoplasms - metabolism
Esophageal Neoplasms - pathology
Esophagus
Female
Gene Expression
Humanities and Social Sciences
Humans
Lymph nodes
Lymphatic Metastasis
Male
Metastases
Metastasis
MicroRNAs - genetics
MicroRNAs - metabolism
Middle Aged
mRNA
multidisciplinary
Neoplasm Invasiveness
Proto-Oncogene Proteins c-akt - biosynthesis
Proto-Oncogene Proteins c-akt - genetics
Proto-Oncogene Proteins c-akt - metabolism
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Science
Science (multidisciplinary)
Tumors
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Zusammenfassung:Esophageal cancer (ECa) remains a major cause of mortality across the globe. The expression of EIF3J-AS1 is altered in a plethora of tumors, but its role in ECa development and progression are undefined. Here, we show that EIF3J-AS1 is up-regulated in ECa and that its expression correlates with advanced TNM stage (P = 0.014), invasion depth (P = 0.001), positive lymph node metastasis (P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-70886-2