Association between Weight Variability, Weight Change and Clinical Outcomes in Hypertension

The effect of body weight variability (BWV) and body weight change (BWC) in high-risk individuals with hypertension, but without diabetes mellitus (DM) remains unclear. We examined the effect of BWV and BWC on the primary outcome [the composite of myocardial infarction (MI), other acute coronary syn...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American journal of preventive cardiology 2023-12, Vol.16, p.100610-100610, Article 100610
Hauptverfasser: Kazibwe, Richard, Singleton, Matthew J., Ahmad, Muhammad Imtiaz, Kaze, Arnaud D., Chevli, Parag A., Namutebi, Juliana H., Kasozi, Ramla N., Asiimwe, Denis D., Kazibwe, Joseph, Shapiro, Michael D., Yeboah, Joseph
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The effect of body weight variability (BWV) and body weight change (BWC) in high-risk individuals with hypertension, but without diabetes mellitus (DM) remains unclear. We examined the effect of BWV and BWC on the primary outcome [the composite of myocardial infarction (MI), other acute coronary syndromes, stroke, acute decompensated heart failure (HF), or cardiovascular (CV) death] and all-cause mortality in the Systolic Blood Pressure Intervention Trial (SPRINT). In this post-hoc analysis, we used multivariate Cox regression models to examine the risk associated with BWV and BWC for the primary outcome in SPRINT. BWV was defined as the intra-individual average successive variability (ASV). BWC was defined as baseline weight minus final weight. A total of 8714 SPRINT participants (mean age 67.8±9.4 years, 35.1% women, 58.9% Whites) who had data on weight were included. The median follow-up was about 3.9 years (IQR, 3.3-4.4). In multivariable-adjusted Cox models, each 1 unit standard deviation (SD) of BWV was significantly associated with a higher risk for the primary outcome, all-cause mortality, HF, MI, and stroke [HR(95% CI)]: 1.13 (1.07 - 1.19; p
ISSN:2666-6677
2666-6677
DOI:10.1016/j.ajpc.2023.100610