Formulation and Development of Oral Fast-Dissolving Films Loaded with Nanosuspension to Augment Paroxetine Bioavailability: In Vitro Characterization, Ex Vivo Permeation, and Pharmacokinetic Evaluation in Healthy Human Volunteers

Formulation and Development of Oral Fast-Dissolving Films Loaded with Nanosuspension to Augment Paroxetine Bioavailability: In Vitro Characterization, Ex Vivo Permeation, and Pharmacokinetic Evaluation in Healthy Human Volunteers

Paroxetine (PX) is the most potent serotonin reuptake inhibitor utilized in depression and anxiety treatment. It has drawbacks, such as having a very bitter taste, low water solubility, and undergoing extensive first pass metabolism, leading to poor oral bioavailability (

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Bibliographische Detailangaben
Veröffentlicht in:Pharmaceutics 2021-11, Vol.13 (11), p.1869
Hauptverfasser: Elshafeey, Ahmed Hassen, El-Dahmy, Rania Moataz
Format: Artikel
Sprache:eng
Schlagworte:
Aluminum
Bioavailability
Cellulose
Drug delivery systems
Drug dosages
ex vivo permeation
factorial design
Glycerol
Mental disorders
Metabolism
Nanoparticles
nanosuspension
oral fast dissolving film
paroxetine
Particle size
Pharmacokinetics
Polyethylene glycol
Polymers
rapid release
Solvents
Tensile strength
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Beschreibung
Zusammenfassung:Paroxetine (PX) is the most potent serotonin reuptake inhibitor utilized in depression and anxiety treatment. It has drawbacks, such as having a very bitter taste, low water solubility, and undergoing extensive first pass metabolism, leading to poor oral bioavailability (
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics13111869