Differential Placental DNA Methylation of NR3C1 in Extremely Preterm Infants With Poorer Neurological Functioning

Differential Placental DNA Methylation of NR3C1 in Extremely Preterm Infants With Poorer Neurological Functioning

BackgroundUnderstanding underlying mechanisms of neurodevelopmental impairment following preterm birth may enhance opportunities for targeted interventions. We aimed to assess whether placental DNA methylation of selected genes affected early neurological functioning in preterm infants. MethodsWe in...

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Veröffentlicht in:Frontiers in pediatrics 2022-06, Vol.10, p.876803-876803
Hauptverfasser: van Dokkum, Nienke H., Bachini, Sofia, Verkaik-Schakel, Rikst Nynke, Baptist, Dyvonne H., Salavati, Sahar, Kraft, Karianne E., Scherjon, Sicco A., Bos, Arend F., Plösch, Torsten
Format: Artikel
Sprache:eng
Schlagworte:
DNA methylation
neurological functioning
Pediatrics
placenta
prematurity
stress
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Zusammenfassung:BackgroundUnderstanding underlying mechanisms of neurodevelopmental impairment following preterm birth may enhance opportunities for targeted interventions. We aimed to assess whether placental DNA methylation of selected genes affected early neurological functioning in preterm infants. MethodsWe included 43 infants, with gestational age
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2022.876803