Urban PM2.5 Induces Cellular Toxicity, Hormone Dysregulation, Oxidative Damage, Inflammation, and Mitochondrial Interference in the HRT8 Trophoblast Cell Line

Urban PM2.5 Induces Cellular Toxicity, Hormone Dysregulation, Oxidative Damage, Inflammation, and Mitochondrial Interference in the HRT8 Trophoblast Cell Line

Epidemiological studies have found air pollution to be a driver of adverse pregnancy outcomes, including gestational diabetes, low term birth weight and preeclampsia. It is unknown what biological mechanisms are involved in this process. A first trimester trophoblast cell line (HTR-8/SVneo) was expo...

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Veröffentlicht in:Frontiers in endocrinology (Lausanne) 2020-03, Vol.11, p.75
Hauptverfasser: Nääv, Åsa, Erlandsson, Lena, Isaxon, Christina, Åsander Frostner, Eleonor, Ehinger, Johannes, Sporre, Moa K, Krais, Annette M, Strandberg, Bo, Lundh, Thomas, Elmér, Eskil, Malmqvist, Ebba, Hansson, Stefan R
Format: Artikel
Sprache:eng
Schlagworte:
Air Pollutants - adverse effects
Air Pollutants - analysis
Air Pollutants - chemistry
air pollution
Apoptosis
Basic Medicine
Cell and Molecular Biology
Cell- och molekylärbiologi
Cells, Cultured
Endocrinology
Female
Hormones - analysis
Humans
inflammation
Inflammation - chemically induced
Inflammation - pathology
Medical and Health Sciences
Medicin och hälsovetenskap
Medicinska och farmaceutiska grundvetenskaper
Mitochondria - drug effects
Mitochondria - pathology
Oxidative Stress
Particulate Matter - adverse effects
Particulate Matter - analysis
Particulate Matter - chemistry
placenta
PM2.5
preeclampsia
Pregnancy
Reactive Oxygen Species - metabolism
trophoblast cells
Trophoblasts - drug effects
Trophoblasts - pathology
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Zusammenfassung:Epidemiological studies have found air pollution to be a driver of adverse pregnancy outcomes, including gestational diabetes, low term birth weight and preeclampsia. It is unknown what biological mechanisms are involved in this process. A first trimester trophoblast cell line (HTR-8/SVneo) was exposed to various concentrations of PM2.5 (PM2.5) in order to elucidate the effect of urban particulate matter (PM) of size
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2020.00075