Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy

[...]selective blocking of these receptors can change the immune cell distribution towards CD8+ immune-competent cell lines. [...]we interbred compound KC mouse mutants with IL-6 knockout allele (Il-6−/−) or the conditional Cxcl12lox/+ allele and analyzed the distribution of immune cells in the pancreas (Supplementary Figure S8A-C). [...]the CD8+:CD11b+ ratio was significantly higher in mice with cytokine depletion (KC vs. [...]the treated animals showed a higher mean 13-week survival rate (Control vs. [...]we showed that autochthonous, oncogenic Kras-based mouse models of PDAC have a specific immune cell distribution in the primary tumor, comparable to human PDAC at only few time points of tumor development.