Metabolic endophenotype associated with right ventricular glucose uptake in pulmonary hypertension

Metabolic endophenotype associated with right ventricular glucose uptake in pulmonary hypertension

Alterations in metabolism and bioenergetics are hypothesized in the mechanisms leading to pulmonary vascular remodeling and heart failure in pulmonary hypertension (PH). To test this, we performed metabolomic analyses on 30 PH individuals and 12 controls. Furthermore, using 2-[18F]fluoro-2-deoxy-D-g...

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Veröffentlicht in:Pulmonary circulation 2021-10, Vol.11 (4), p.1-12
Hauptverfasser: Farha, Samar, Comhair, Suzy, Hou, Yuan, Park, Margaret M., Sharp, Jacqueline, Peterson, Laura, Willard, Belinda, Zhang, Renliang, DiFilippo, Frank P., Neumann, Donald, Tang, W.H. Wilson, Cheng, Feixiong, Erzurum, Serpil
Format: Artikel
Sprache:eng
Schlagworte:
arginine
FDG‐PET scan
Glucose
Metabolism
metabolomics
Original
outcomes
Pulmonary hypertension
tricarboxylic acid cycle
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Zusammenfassung:Alterations in metabolism and bioenergetics are hypothesized in the mechanisms leading to pulmonary vascular remodeling and heart failure in pulmonary hypertension (PH). To test this, we performed metabolomic analyses on 30 PH individuals and 12 controls. Furthermore, using 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography, we dichotomized PH patients into metabolic phenotypes of high and low right ventricle (RV) glucose uptake and followed them longitudinally. In support of metabolic alterations in PH and its progression, the high RV glucose group had higher RV systolic pressure (p 
ISSN:2045-8940
2045-8932
2045-8940
DOI:10.1177/20458940211054325