A Hypoxia-Regulated Adeno-Associated Virus Vector for Cancer-Specific Gene Therapy

The presence of hypoxic cells in human brain tumors is an important factor leading to resistance to radiation therapy. However, this physiological difference between normal tissues and tumors also provides the potential for designing cancer-specific gene therapy. We compared the increase of gene exp...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neoplasia (New York, N.Y.) N.Y.), 2001, Vol.3 (3), p.255-263
Hauptverfasser:	Ruan, Hangjun, Sutt, Hua, Hu, Lily, Lamborn, Kathleen R., Kan, Y.W., Deen, Dennis F
Format:	Artikel
Sprache:	eng
Schlagworte:	adeno-associated virus Adenoviridae - genetics beta-Galactosidase - metabolism Blotting, Western Brain Neoplasms - metabolism Brain Neoplasms - therapy brain tumor cells DNA-Binding Proteins - metabolism erythropoietin Gene Dosage Gene Expression Regulation, Neoplastic gene therapy Genes, Reporter Genetic Therapy Genetic Vectors Glioblastoma - metabolism Glioblastoma - therapy Humans hypoxia Hypoxia, Brain - metabolism Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1, alpha Subunit hypoxia-responsive element hypoxia-responsive elements Lac Operon - genetics LacZ gene Nuclear Proteins - metabolism Oxygen - metabolism Plasmids Promoter Regions, Genetic Proto-Oncogene Proteins - biosynthesis Transcription Factors Transcriptional Activation Transfection Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The presence of hypoxic cells in human brain tumors is an important factor leading to resistance to radiation therapy. However, this physiological difference between normal tissues and tumors also provides the potential for designing cancer-specific gene therapy. We compared the increase of gene expression under anoxia (
ISSN:	1476-5586 1522-8002 1476-5586 1522-8002
DOI:	10.1038/sj.neo.7900157