Prenatal air pollution, maternal immune activation, and autism spectrum disorder

Prenatal air pollution, maternal immune activation, and autism spectrum disorder

[Display omitted] •Prenatal conditions of maternal immune activation (MIA) was associated with ASD.•Exposure to PM2.5 and its major components during pregnancy were associated with ASD.•Prenatal MIA conditions unexpectedly did not augment effects of particles on ASD. Autism Spectrum Disorder (ASD) r...

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Veröffentlicht in:Environment international 2023-09, Vol.179, p.108148-108148, Article 108148
Hauptverfasser: Yu, Xin, Mostafijur Rahman, Md, Carter, Sarah A., Lin, Jane C., Zhuang, Zimin, Chow, Ting, Lurmann, Frederick W., Kleeman, Michael J., Martinez, Mayra P., van Donkelaar, Aaron, Martin, Randall V., Eckel, Sandrah P., Chen, Zhanghua, Levitt, Pat, Schwartz, Joel, Hackman, Daniel, Chen, Jiu-Chiuan, McConnell, Rob, Xiang, Anny H.
Format: Artikel
Sprache:eng
Schlagworte:
aerodynamics
air pollution
Air Pollution - adverse effects
Asthma
autism
Autism Spectrum Disorder - epidemiology
Autism Spectrum Disorder - etiology
Autism spectrum disorders
autoimmune diseases
bioactive properties
California
carbon
Child, Preschool
confidence interval
environment
Female
hazard ratio
Humans
Hypertension
Interaction
maternal exposure
nitrates
organic matter
particulates
PM2.5
PM2.5 chemical components
Pregnancy
regression analysis
risk
sulfates
Susceptibility
Vitamins
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Zusammenfassung:[Display omitted] •Prenatal conditions of maternal immune activation (MIA) was associated with ASD.•Exposure to PM2.5 and its major components during pregnancy were associated with ASD.•Prenatal MIA conditions unexpectedly did not augment effects of particles on ASD. Autism Spectrum Disorder (ASD) risk is highly heritable, with potential additional non-genetic factors, such as prenatal exposure to ambient particulate matter with aerodynamic diameter 
ISSN:0160-4120
1873-6750
1873-6750
DOI:10.1016/j.envint.2023.108148