Chemical Review of Gorgostane-Type Steroids Isolated from Marine Organisms and Their 13C-NMR Spectroscopic Data Characteristics

Chemical Review of Gorgostane-Type Steroids Isolated from Marine Organisms and Their 13C-NMR Spectroscopic Data Characteristics

Gorgostane steroids are isolated from marine organisms and consist of 30 carbon atoms with a characteristic cyclopropane moiety. From the pioneering results to the end of 2021, isolation, biosynthesis, and structural elucidation using 13C-NMR will be used. Overall, 75 compounds are categorized into...

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Veröffentlicht in:Marine drugs 2022-02, Vol.20 (2), p.139
Hauptverfasser: Abdelkarem, Fahd M., Abouelela, Mohamed E., Kamel, Mohamed R., Nafady, Alaa M., Allam, Ahmed E., Abdel-Rahman, Iman A. M., Almatroudi, Ahmad, Alrumaihi, Faris, Allemailem, Khaled S., Assaf, Hamdy K.
Format: Artikel
Sprache:eng
Schlagworte:
13C-NMR
Biodiversity
Biological effects
Biosynthesis
Carbon
Cyclopropane
Cytotoxicity
gorgostane
Marine biology
Marine organisms
NMR
Nuclear magnetic resonance
Organisms
Review
Selectivity
Steroid hormones
Steroids
Sterols
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Zusammenfassung:Gorgostane steroids are isolated from marine organisms and consist of 30 carbon atoms with a characteristic cyclopropane moiety. From the pioneering results to the end of 2021, isolation, biosynthesis, and structural elucidation using 13C-NMR will be used. Overall, 75 compounds are categorized into five major groups: gorgost-5-ene, 5,6-epoxygorgostane, 5,6-dihydroxygorgostane, 9,11-secogorgostane, and 23-demethylgorgostane, in addition to miscellaneous gorgostane. The structural diversity, selectivity for marine organisms, and biological effects of gorgostane steroids have generated considerable interest in the field of drug discovery research.
ISSN:1660-3397
1660-3397
DOI:10.3390/md20020139