Sitting intolerance: A new disease entity in children and adolescents

[...]far, the epidemiological characteristics and exact incidence of sitting intolerance remain unclear. [...]multi-center studies across countries are needed to determine the epidemiological characteristics of this disease, which will, of course, provide insights concerning its treatment and prevention. In terms of pathogenesis, the underlying hemodynamic changes and humoral mechanisms have not been elucidated. [...]laboratory investigations are needed at the molecular, cellular, pathophysiological, electrophysiological, and genetic levels; and through such studies, the statuses of body fluids, vascular function, inflammation, immune responses, and sympathetic nerve activity should be elucidated. [...]therapeutic options for sitting intolerance are limited right now, and there is a critical need to discover new drug targets and treatment options.