Adverse effects of dupilumab in chronic rhinosinusitis with nasal polyps. Case report and narrative review

Herein we review the current literature on the adverse effects related to biological therapy with the monoclonal antibody dupilumab in patients with type 2 inflammation prevalent phenotype chronic rhinosinusitis with nasal polyps (CRSwNP). Our review shows that the side effects of dupilumab may be l...

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Veröffentlicht in:	Acta otorhino-laryngologica italica 2022-06, Vol.42 (3), p.199-204
Hauptverfasser:	Nitro, Letizia, Bulfamante, Antonio Mario, Rosso, Cecilia, Saibene, Alberto Maria, Arnone, Flavio, Felisati, Giovanni, Pipolo, Carlotta
Format:	Artikel
Sprache:	eng
Schlagworte:	Review
Online-Zugang:	Volltext
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Zusammenfassung:	Herein we review the current literature on the adverse effects related to biological therapy with the monoclonal antibody dupilumab in patients with type 2 inflammation prevalent phenotype chronic rhinosinusitis with nasal polyps (CRSwNP). Our review shows that the side effects of dupilumab may be linked to the prevalent type 2 inflammation phenotype (asthma, dermatitis, CRSwNP). We also report the first case of cutaneous rash as a side effect of dupilumab in a patient with CRSwNP.
ISSN:	1827-675X 0392-100X 1827-675X
DOI:	10.14639/0392-100X-N1911