Exposure to Toxocara spp. and Ascaris lumbricoides infections and risk of allergic rhinitis in children

Substantial experimental studies suggest a role for helminthes infections in the pathogenesis of allergies, but epidemiologic data have been inconsistent. Unlike to asthma, the association between helminthes infection and allergic rhinitis (AR) has been poorly studied. Therefore, we sought to evalua...

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Veröffentlicht in:Allergy, asthma, and clinical immunology asthma, and clinical immunology, 2020-07, Vol.16 (1), p.69-69, Article 69
Hauptverfasser: Mohammadzadeh, Iraj, Darvish, Sorena, Riahi, Seyed Mohammad, Moghaddam, Solmaz Alizadeh, Pournasrollah, Mohammad, Mohammadnia-Afrozi, Mousa, Rostami, Ali
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Sprache:eng
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Zusammenfassung:Substantial experimental studies suggest a role for helminthes infections in the pathogenesis of allergies, but epidemiologic data have been inconsistent. Unlike to asthma, the association between helminthes infection and allergic rhinitis (AR) has been poorly studied. Therefore, we sought to evaluate the association between exposure to and infections and AR. We did an age- and gender-matched case-control study of 81 children with physician-confirmed AR and 101 control subjects in a referral hospital for pediatric diseases in northern Iran. Exposure to and infections was evaluated by anti- - and anti- - IgG antibodies using a commercial enzyme-linked immunosorbent assay. Associations were determined using multivariate logistic regression. seropositivity was higher in children with rhinitis than in controls (12.34 vs. 3.96%). seropositivity was positively associated with AR in univariate analysis (OR, 3.42; 95% CI 1.03-11.3; P value = 0.035), but this association was not significant after adjustment for potential confounders (OR, 1.85; 95% CI 0.42-8.18). Also seropositivity was higher in children with AR than in healthy subjects (3.7% vs. 0.99), indicating non-significant association with AR in both univariate (OR, 3.84; 95% CI 0.39-37.7) and multivariate analyses (OR, 0.8; 95% CI 0.04-15.44). Our results revealed that AR is not associated with seropositivity to and infections in general; however, a higher seropositivity rate was found for both parasites in children with AR. More studies with longitudinal design and larger sample size are needed to elucidate this association.
ISSN:1710-1484
1710-1492
1710-1492
DOI:10.1186/s13223-020-00468-4