Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years

Immune response induced by COVID-19 vaccine booster against delta and omicron variants was assessed in 65 adults (65–84 years old) early aftesr a first booster dose. An increase in SARS-CoV-2 neutralizing antibodies was shown in individuals not previously infected without evidence of an age-related...

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Veröffentlicht in:	Scientific reports 2022-11, Vol.12 (1), p.20373-20373, Article 20373
Hauptverfasser:	Durier, Christine, Ninove, Laetitia, Lefebvre, Maeva, Radenne, Anne, Desaint, Corinne, Ropers, Jacques, Bauer, Rebecca, Lebbah, Said, Carette, Diane, Lachatre, Marie, Lecompte, Anne-Sophie, Deplanque, Dominique, Botelho-Nevers, Elisabeth, Conrad, Anne, Dussol, Bertrand, Maakaroun-Vermesse, Zoha, Melica, Giovanna, Nicolas, Jean-François, Verdon, Renaud, Kiladjian, Jacques, Loubet, Paul, Schmidt-Mutter, Catherine, Dualé, Christian, Ansart, Séverine, Priet, Stéphane, Levier, Axel, Molino, Diana, Vieillard, Louis-Victorien, Parfait, Béatrice, Lelièvre, Jean-Daniel, Tartour, Eric, de Lamballerie, Xavier, Launay, Odile
Format:	Artikel
Sprache:	eng
Schlagworte:	692/308 692/53 Age Aged Aged, 80 and over Antibodies Antibodies, Neutralizing Antibodies, Viral Coronaviruses COVID-19 COVID-19 - prevention & control COVID-19 vaccines Disease Humanities and Social Sciences Humans Immune response Immune response (humoral) Immunology Infections Life Sciences mRNA multidisciplinary Neutralization Tests Older people RNA, Messenger SARS-CoV-2 - genetics Science Science (multidisciplinary) Serology Severe acute respiratory syndrome coronavirus 2 Vaccination Vaccinology Viral Vaccines
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Beschreibung
Zusammenfassung:	Immune response induced by COVID-19 vaccine booster against delta and omicron variants was assessed in 65 adults (65–84 years old) early aftesr a first booster dose. An increase in SARS-CoV-2 neutralizing antibodies was shown in individuals not previously infected without evidence of an age-related effect, with lower increase in those infected before a single dose of primary vaccination. Of note, humoral response was observed only starting from the 5th day after the boost.
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-022-24409-w