Is there a connection between iron exchange and COVID-19?

Is there a connection between iron exchange and COVID-19?

The review analyzes possible epidemiological and molecular mechanisms responsible for hyperinflammation in patients with the severe course of COVID-19.Results: it highlights the similarities between this condition and hyperferritinemic syndrome which allows considering pathogenesis of COVID-19 with...

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Veröffentlicht in:Vestnik anesteziologii i reanimatologii 2020-09, Vol.17 (4), p.6-13
Hauptverfasser: Orlov, Yu. P., Dolgikh, V. T., Vereschagin, E. I., Lukach, V. N., Govorova, N. V., Kokhno, V. N., Shmakov, A. N., Patyukov, Ya. N.
Format: Artikel
Sprache:eng
Schlagworte:
covid-19
cytokine storm
hyperferritinemia
iron chelators
iron metabolism
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Zusammenfassung:The review analyzes possible epidemiological and molecular mechanisms responsible for hyperinflammation in patients with the severe course of COVID-19.Results: it highlights the similarities between this condition and hyperferritinemic syndrome which allows considering pathogenesis of COVID-19 with the direct involvement of iron metabolism. In the case of COVID-19 infection of moderate severity and especially in its severe forms, it is indicated to use of iron chelators and other methods of free iron elimination.
ISSN:2078-5658
2541-8653
DOI:10.21292/2078-5658-2020-17-4-6-13