mRNA EXPRESSION OF SOME CHEMOKINES AND THEIR RECEPTORS IN NASAL MUCOSA OF HEALTHY PERSONS

Chemokines are a key factor that ensures the participation of different cell types in the immunological protection of mucosa. In our study we chose some chemokines that ensured the chemotaxis of neutrophils (CXCL8/IL-8), eosinophils (CCL11/eotaxin, CCL24/eotaxin-2), monocytes and T-lymphocytes (CCL3/MIP-1α, CCL4/MIP-1β, CCL5/RANTES), as well as their receptors (CCR1, CCR3, CCR5, CXCR1, CXCR2). mRNA expression of chemokines and their receptors in nasopharyngeal mucosa brush-biopsy specimens determined by RT-PCR in healthy persons, the level of the same chemokines in serum determined by multiplex chemiluminescent assay were analyzed according to smoking. The level of mRNA expression of IL-8 (p < 0.001) and RANTES (p < 0.001) in nasopharynx brush-biopsy specimens and serum levels of IL-8 (p