Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light

Highlights The MoS 2 nanosheets served as co-catalyst could reduce Fe 3+ ions with lower Fenton reaction activity into the highly reactive Fe 2+ ions, thereby boosting the production of hydroxyl radical (•OH) for high efficiency chemodynamic therapy (CDT). The photothermal effect of MoS 2 nanosheets motivated by second near-infrared light could further improve the treatment effectiveness by synergetic photothermal-enhanced CDT and photothermal therapy. In spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction (i.e., chemodynamic therapy, CDT) has been attracted more attentions in recent years, the limited Fenton reaction efficiency is the important obstacle to further application in clinic. Herein, we synthesized novel FeO/MoS 2 nanocomposites modified by bovine serum albumin (FeO/MoS 2 -BSA) with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS 2 nanosheets triggered by the second near-infrared ( NIR II) light. In the tumor microenvironments, the MoS 2 nanosheets not only can accelerate the conversion of Fe 3+ ions to Fe 2+ ions by Mo 4+ ions on their surface to improve Fenton reaction efficiency, but also endow FeO/MoS 2 -BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy (PTT). Consequently, benefiting from the synergetic-enhanced CDT/PTT, the tumors are eradicated completely in vivo. This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT.