Study on the regulation of degradation performance of polyethylene glycol nanofiber membranes by urushiol

This study explores a new type of nanofiber membrane using water-soluble polymer material, polyethylene glycol (PEG), as the main raw material. The membrane is prepared by combining PEG with polyvinyl pyrrolidone (PVP) and urushiol (UR) through electrospinning. The research findings demonstrate that the degradation rate of the nanofiber membrane can be controlled by adjusting the UR content, enabling the production of wound dressings that match the required healing time. Additionally, the addition of UR provides the nanofiber membrane with certain antimicrobial effects against Escherichia coli and Staphylococcus aureus. When combined with nano zinc oxide (ZnO), the antimicrobial effect of the nanofiber membrane reaches 99%. Furthermore, cytotoxicity experiments conducted on the nanofiber membrane meet the relevant standards. The results of this study provide a reliable option for researching and developing PEG materials with improved drug delivery effects. The nanofiber membrane possesses the characteristic of regulating degradation rate and shows potential for application in the field of wound healing, providing support for wound repair and tissue remodeling. •This article offers a novel approach to enhance drug delivery using polyethylene glycol (PEG) materials.•The nanofiber membrane's degradation rate is modulatable via UR content adjustment, facilitating tailored wound dressings aligned with specific healing timelines.•Antimicrobial efficacy of nanofiber membrane demonstrated, enhanced to 99% with nano zinc oxide (ZnO) addition.