Senescent cancer-associated fibroblasts facilitate tumor associated neutrophil recruitment suppressing tumor immunity

[...]its effectiveness is limited due to the heterogeneity and complexity of the tumor microenvironment, not all patients benefit from this therapeutic approach. [...]a comprehensive exploration of the mechanisms underlying immune suppression holds great significance in prognosis for NSCLC patients. [...]this study focuses on exploring the impact of CAFs senescence on tumor immunity in lung adenocarcinoma (Additional file 1). Additionally, Alvaro Teijeira's team discovered that NETs interfered with the contact between cytotoxic T cells/NK cells and tumor cells, inhibiting immune cell-mediated killing effects. [...]we speculate that, the phenomenon in our study that senescent CAFs promoting neutrophil recruitment and thereby inhibiting T cell-induced immunosuppression may also be related to NETs formation; we will further study it in the future.The methods section is elaborated in Additional file 1: