Chemical Diversity and Biological Activity of Secondary Metabolites Isolated from Indonesian Marine Invertebrates

Marine invertebrates have been reported to be an excellent resource of many novel bioactive compounds. Studies reported that Indonesia has remarkable yet underexplored marine natural products, with a high chemical diversity and a broad spectrum of biological activities. This review discusses recent...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2021-03, Vol.26 (7), p.1898
Hauptverfasser:	Izzati, Fauzia, Warsito, Mega Ferdina, Bayu, Asep, Prasetyoputri, Anggia, Atikana, Akhirta, Sukmarini, Linda, Rahmawati, Siti Irma, Putra, Masteria Yunovilsa
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Animals Anthozoa - chemistry Anthozoa - metabolism Anti-Infective Agents - chemistry Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology Antiinfectives and antibacterials Antimicrobial agents Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Aquatic Organisms Bioactive compounds Biological activity Biological Products - chemistry Biological Products - isolation & purification Biological Products - pharmacology Cancer Corals Cytotoxicity E coli FDA approval Fungicides Humans Indonesia Invertebrates Kinases Marine invertebrates marine natural product Metabolites Natural products Peptides - chemistry Peptides - isolation & purification Peptides - pharmacology Polyketides - chemistry Polyketides - isolation & purification Polyketides - pharmacology Porifera - chemistry Porifera - metabolism Review Secondary Metabolism - physiology Secondary metabolites soft corals sponges Structure-Activity Relationship Terpenes - chemistry Terpenes - isolation & purification Terpenes - pharmacology tunicates Urochordata - chemistry Urochordata - metabolism
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Zusammenfassung:	Marine invertebrates have been reported to be an excellent resource of many novel bioactive compounds. Studies reported that Indonesia has remarkable yet underexplored marine natural products, with a high chemical diversity and a broad spectrum of biological activities. This review discusses recent updates on the exploration of marine natural products from Indonesian marine invertebrates (i.e., sponges, tunicates, and soft corals) throughout 2007-2020. This paper summarizes the structural diversity and biological function of the bioactive compounds isolated from Indonesian marine invertebrates as antimicrobial, antifungal, anticancer, and antiviral, while also presenting the opportunity for further investigation of novel compounds derived from Indonesian marine invertebrates.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules26071898