Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland

Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland

We examined virus genomic evolution in an immunocompromised patient with prolonged severe acute respiratory syndrome coronavirus 2 infection. Genomic sequencing revealed genetic variation during infection: 3 intrahost mutations and possible superinfection with a second strain of the virus. Prolonged...

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Veröffentlicht in:Emerging infectious diseases 2021-09, Vol.27 (9), p.2499-2501
Hauptverfasser: Lynch, Maureen, Macori, Guerrino, Fanning, Seamus, ORegan, Edel, Hunt, Eoin, O'Callaghan, Dermot, McCullagh, Brian, Jennings, Cormac, Fortune, Anne
Format: Artikel
Sprache:eng
Schlagworte:
2019 novel coronavirus disease
Case studies
coronavirus disease
Coronaviruses
COVID-19
Disease transmission
Emergency medical care
Genetic aspects
Genetic variation
Genomes
Genomic Evolution of SARS-CoV-2 in Immunocompromised Patient, Ireland
Immunocompromised host
Lymphoma
Monoclonal antibodies
Mutation
Nosocomial infections
Pandemics
Pathogens
Patients
Research Letter
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Viruses
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Zusammenfassung:We examined virus genomic evolution in an immunocompromised patient with prolonged severe acute respiratory syndrome coronavirus 2 infection. Genomic sequencing revealed genetic variation during infection: 3 intrahost mutations and possible superinfection with a second strain of the virus. Prolonged infection in immunocompromised patients may lead to emergence of new virus variants.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2709.211159