Biometabolites of Tamarindus indica play a remarkable cardioprotective role as a functional food in doxorubicin-induced cardiotoxicity models

[Display omitted] •Tamarindus indica is unfolded as a strong antioxidative functional food.•Tamarindus normalized lipid profiles in doxorubicin-induced cardiotoxicity.•Biometabolites-cardiac receptor protein interactions were close to Valsartan.•Heart markers (CK-MB, LDH and Troponin I) were remarkably reduced in cardiac injury.•Cardiac tissue architecture was restored to play a protective role. This research investigated the cardioprotectiveeffectsofTamarindus indica extracts (TIEx) in doxorubicin (Dox)-induced cardiotoxicity model. TIEx was tested for phytochemical and antioxidative status followed by a randomized controlled intervention in Swiss albino models. The results were verified by in silico interactions of GC-MS characterized phytocompounds against AT1 (angiotensin II type 1) receptor antagonist complexed with PPARγ agonist. TIEx showed an excellent antioxidative effect and a significant (P