Hypoxic colorectal cancer‐derived extracellular vesicles deliver microRNA‐361‐3p to facilitate cell proliferation by targeting TRAF3 via the noncanonical NF‐κB pathways

Background Hypoxic tumour microenvironment (TME) is a key regulator in cancer progression. However, the communications between hypoxic cells and other components in TME during colorectal cancer (CRC) progression via extracellular vesicles (EVs) remain unclear. Methods High‐throughput sequencing was...

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Veröffentlicht in:	Clinical and translational medicine 2021-03, Vol.11 (3), p.e349-n/a
Hauptverfasser:	Li, Jie, Yang, Peng, Chen, Fangyu, Tan, Yuqian, Huang, Changzhi, Shen, Hengyang, Peng, Chaofan, Feng, Yifei, Sun, Yueming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cancer therapies Cell cycle Cell growth Cell Proliferation - genetics Clinical medicine Colorectal cancer Colorectal Neoplasms - complications Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Cyclin-dependent kinases Disease Models, Animal Extracellular vesicles Extracellular Vesicles - genetics Extracellular Vesicles - metabolism Gene Expression Regulation, Neoplastic - genetics Humans Hypoxia Hypoxia - complications Kinases Medical prognosis Metastasis Mice MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Microscopy miR‐361‐3p NF-kappa B - genetics NF-kappa B - metabolism noncanonical NF‐κB Plasmids TNF Receptor-Associated Factor 3 - genetics TNF Receptor-Associated Factor 3 - metabolism Tumor Microenvironment - genetics Tumors
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Zusammenfassung:	Background Hypoxic tumour microenvironment (TME) is a key regulator in cancer progression. However, the communications between hypoxic cells and other components in TME during colorectal cancer (CRC) progression via extracellular vesicles (EVs) remain unclear. Methods High‐throughput sequencing was employed to detect aberrantly expressed microRNAs (miRNAs) in hypoxic EVs. Quantitative real‐time PCR was used to confirm and screen preliminarily candidate miRNAs. The effects of EVs derived from hypoxia (
ISSN:	2001-1326 2001-1326
DOI:	10.1002/ctm2.349