Drug-induced liver injuries in pregnancy in the context of polypragmasy

Pregnancy is characterized by overexertion of metabolism in the liver and some changes in metabolism, which can lead to various, including severe organ, damage. During pregnancy, according to international epidemiological studies, more than 80 % of women take medicines. Under polypragmasy it is extr...

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Veröffentlicht in:	Bezopasnostʹ i risk farmakoterapii (Online) 2018-02, Vol.5 (3), p.104-111
Hauptverfasser:	N. Yu. Velts, E. O. Zhuravleva, M. A. Darmostukova, K. E. Zatolochina, O. S. Alyautdina
Format:	Artikel
Sprache:	rus
Schlagworte:	drug safety drug-induced hepatitis gestagens multivitamins pregnancy russian ais database roszdravnadzor pharmacovigilance spontaneous reports безопасность лекарственных средств беременность гестагены лекарственный гепатит поливитамины российская база аис росздравнадзор «фармаконадзор спонтанные сообщения
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Beschreibung
Zusammenfassung:	Pregnancy is characterized by overexertion of metabolism in the liver and some changes in metabolism, which can lead to various, including severe organ, damage. During pregnancy, according to international epidemiological studies, more than 80 % of women take medicines. Under polypragmasy it is extremely difficult to isolate a particular medicine responsible for the drug pathology in the liver in pregnant women. The article presents a retrospective analysis of spontaneous reports accepted from the Russian database of AIS Roszdravnadzor for the period from 01.01.2009 to 31.12.2016.
ISSN:	2312-7821 2619-1164