Association of Serum Amylase Activity and the Copy Number Variation of AMY1/2A/2B with Metabolic Syndrome in Chinese Adults

Low serum amylase activity and copy number (CN) variation (CNV) of the salivary amylase gene ( ) are reportedly associated with obesity and abnormal glucose metabolism; however, this association remains controversial. We aimed to clarify the relationship between serum amylase activity and the CNV of with the occurrence of metabolic syndrome (MetS) in Chinese adults. Anthropometry, metabolic risk factors, and serum amylase activity were assessed in 560 subjects (260 MetS patients; 300 healthy controls). CNs were evaluated using the highly sensitive droplet digital PCR. The serum total, pancreatic, and salivary amylase activity, but not the CNs, was significantly lower in MetS patients than that in the control subjects. Patients