Engineering Core-Shell Structures of Magnetic Ferrite Nanoparticles for High Hyperthermia Performance

Magnetic ferrite nanoparticles (MFNs) with high heating efficiency are highly desirable for hyperthermia applications. As conventional MFNs usually show low heating efficiency with a lower specific loss power ( ), extensive efforts to enhance the of MFNs have been made by varying the particle compositions, sizes, and structures. In this study, we attempted to increase the values by creating core-shell structures of MFNs. Accordingly, first we synthesized three different types of core ferrite nanoparticle of magnetite (mag), cobalt ferrite (cf) and zinc cobalt ferrite (zcf). Secondly, we synthesized eight bi-magnetic core-shell structured MFNs; Fe O @CoFe O (mag@cf , mag@cf ), CoFe O @Fe O (cf@mag , cf@mag ), Fe O @ZnCoFe O (mag@zcf , mag@zcf ), and ZnCoFe O @Fe O (zcf@mag , zcf@mag ), using a modified controlled co-precipitation process. values of the prepared core-shell MFNs were investigated with respect to their compositions and core/shell dimensions while varying the applied magnetic field strength. Hyperthermia properties of the prepared core-shell MFNs were further compared to commercial magnetic nanoparticles under the safe limits of magnetic field parameters (