Comparative analysis of platelet rich plasma usage effect in monotherapy or in combination with 0.01% sulfated glycosaminoglycans in patients with chronic corneal de-epithelialization of herpesvirus etiology

Purpose. To estimate an effectiveness of platelet-rich plasma (PRP) in monotherapy or in combination with 0.01% sulfated glycosaminoglycans for the treatment of herpetic recurrent cornea erosion syndrome.Material and methods. The study involved 60 patients. All patients had in anamnesis unilateral Herpetic keratitis, with the formation of a chronic corneal epithelialization disorder as an outcome. All of them had previously unsuccessful courses of reparative therapy. The first step of the treatment included local and systemic antiviral and reparative therapies. At the 2-nd step, the group 1 (30 patients) received the PRP therapy 6 times daily, the group 2 (30 patients) received the PRP therapy 6 times daily in the combination with instillations of 0.01% sulfated glycosaminoglycans (Balarpan-N) 4 times daily. The control group was the condition of the patients before the beginning of the PRP therapy.Results. The positive effect of the methods was demonstrated. Using PRP in monotherapy or in combination with 0.01% sulfated glycosaminoglycans showed an improvement in epithelialization.Conclusions. The comparative analysis with standard methods of therapy showed a positive dynamic of PRP treatment in patients with a previously ineffective therapy.