Nutraceutical potential of Amazonian oilseeds in modulating the immune system against COVID-19 – A narrative review

[Display omitted] •The constituents of Amazonian oilseeds promote the modulation of the immune system.•PUFAs act on signaling pathways that regulate the anti-inflammatory system.•Vitamins present in oilseeds regulate adaptive response of NK and T cells.•Minerals, such as selenium and zinc, promote oxidative homeostasis.•Lipids are promising materials for drug delivery systems, e.g., nanoencapsulation. Since the outbreak of COVID-19 disease, medical and scientific communities are facing a challenge to contain its spread, develop effective treatments, and reduce its sequelae. Together with the therapeutical treatments, the use of dietary bioactive compounds represents a promising and cost-effective strategy to modulate immunological responses. Amazonian oilseeds are great sources of bioactive compounds, thus representing not only a dietary source of nutrients but also of substances with great interest for human health. This narrative review compiled the available evidence regarding the biochemical properties of some Amazonian oilseeds, especially Brazil nut, Açaí berry, Bacaba, Peach palm, Sapucaya and Tucuma fruits, on human health and its immune system. These effects were discussed from an etiological and pathophysiological perspective, emphasizing their potential role as a co-adjuvant strategy against COVID-19. Besides this, the cost associated with these strategies hinders their applicability in many nations, especially low-income countries and communities living in social insecurity.