Anti-oxidant, anti-apoptotic, and protective effects of myricitrin and its solid lipid nanoparticle on streptozotocin-nicotinamide induced diabetic nephropathy in type 2 diabetic male mice

[...]when the number of functioning glomeruli is substantially reduced, the total GFR may be within the normal range despite single glomerular hyperfiltration. [...]it can be concluded that although the level of creatinine in the plasma sometimes increases in some nephropathies, GFR is high. According to the GFR formula, increased serum creatinine can result in GFR reduction but in some situations, this reduction of GFR is strongly affected by the increase in the urine volume (7). According to studies conducted in this field, one of the reasons for the increase in glomerular filtration in the first stage of diabetes is the increase in glomerular hydrostatic pressure, which occurs as a result of the activation of the Renin-angiotensin-aldosterone system (RAAS). [...]it is logical that the secretion of aldosterone causes an increase in sodium in the blood and a decrease in its excretion (8).